A recent study suggests that patients who discontinue blockbuster weight-loss injections like semaglutide or tirzepatide tend to recover reduced body mass at a significantly accelerated pace than those who halt conventional diet and exercise programs.
Findings released in a prominent health publication points out that while obese people often shed a large proportion of their body weight while on the medication, the mass comes back at an average rate of nearly a kilo each month after stopping.
"Individuals using these medications should be aware of the danger of rapid rebound weight gain when the medication ends," stated expert Dr. Susan Jebb.
Such speed of recovery suggests a return to pre-treatment mass within about 18 months.
Comparing Treatments
The research, which reviewed 37 of studies involving thousands of patients, compared the results of the injectable medications with older methods.
Researchers emphasize that people who shed pounds through lifestyle changes alone typically have a less rapid weight regain—approximately 0.1 kg a month—post-intervention.
The Reason for the Quick Regain
Experts suggest the mode of action of the injections accounts for the heightened rebound.
The injections copy a body's own chemical called GLP-1, which helps regulate hunger.
"Sustained high doses of GLP-1 concentrations several times higher than the body's typical production could lead to the system to produce less of its endogenous hormone, and could reduce responsiveness to its effects," noted Dr. Adam Collins, a dietetics researcher.
"Withdrawal of this medication means hunger is unsuppressed, making excessive eating a significant risk."
A Chronic Condition?
The NHS suggest the injections for people with obesity-related medical conditions, alongside recommended lifestyle changes.
Many experts contend that, given the likelihood of weight regain, the treatment should be considered ongoing.
This opinion is supported by drug manufacturers, who state that the results "underscore the chronic nature of obesity," similar to managing diseases like high blood pressure.
Patient Experiences
People who have stopped the jabs explain a intense return of cravings.
"It felt as if something that goes on and I was suddenly extremely hungry," described a patient.
This difficulty is exacerbated if patients have not adopted sustainable lifestyle or habit changes during treatment.
Growing Interest
Recent estimates indicate that a significant number of people in the UK have tried these injections in the last 12 months, with interest continuing to grow.
- Use is more common among women compared to males.
- The middle-aged age group shows the highest level of interest.
- A large proportion obtain the medications through private healthcare rather than public health services.
In conclusion, researchers emphasize that while the jabs are effective agents for weight loss, they are not a permanent fix and lasting health benefits relies on combined lifestyle changes.
